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. 2014 Feb 3;592(Pt 5):941–969. doi: 10.1113/jphysiol.2013.266866

Figure 13. Prototypical cardiotonic steroid skeleton core .

Figure 13

The primary features are a steroid skeleton in which the rings are fused in a cistranscis arrangement. All ouabain‐like steroids in this study have a 14β‐OH, an unsaturated lactone ring attached via C17 in the β configuration, and a methyl group at C18. The sugars, if present, are attached via the 3β‐OH. See text for details. Reproduced with permission from Manunta et al. (2000).