Figure 2.

A, effect of the 3 month exercise intervention on body weight, lean body mass and fat mass in all 16 participants. Effect of the 3 month exercise intervention and an acute bout of exercise (sampled 60–90 min post exercise) on skeletal muscle Fndc5 mRNA (B and C) and on the circulating irisin levels (D). E, associations of circulating irisin with muscle mass (calf volume), strength (maximal voluntary contraction force) and contractility (rate of force development); ○ before training, • after training. Data are shown as means ± SEM.