Figure 11.

A–C, time course of mean arterial pressure (MAP) in mice in the low K⁺ (A, 0.03% K⁺, 3% Na⁺; n = 5), normal K⁺ (B, 0.93% K⁺, 3% Na⁺; n = 3) and high K⁺ (C, 5% K⁺, 3% Na⁺; n = 5) groups treated with spironolactone (175 mg kg⁻¹ per day) compared with MAP in mice on the control diet (0.93% K⁺, 0.24% Na⁺). D–F, MAP_night in mice on the control diet in comparison with MAP_night in mice treated with spironolactone and the experimental diets. (Mean ± s.e.m; *P < 0.05, **P < 0.01, Student's paired t test).