Figure 12.

A, B, time course of mean arterial pressure (MAP) in mice in the high K⁺ (5% K⁺, 3% Na⁺) group treated with a high dosage of spironolactone (665 mg kg⁻¹ per day; n = 4) or amiloride (4.8 mg kg⁻¹ per day; n = 5) compared with MAP in mice fed control diet (0.93% K⁺, 0.24% Na⁺). C, D, MAP_night in mice fed control diet in comparison with MAP_night in mice in the high K⁺ (5% K⁺, 3% Na⁺) group additionally treated with spironolactone (C) or amiloride (D) (mean ± s.e.m; **P < 0.01,***P < 0.01, Student's paired t test). Blood pressure recordings were performed for 48 h before the experimental diet was started and again in the same mice at the end of the experimental period.