Table 1.
Physiological parameters in Na+ replete mice fed different K+ diets
| Low K+ group 0.03% K+, 3% Na+ | Normal K+ group 0.93% K+, 3% Na+ | High K+ group 5% K+, 3% Na+ | |
|---|---|---|---|
| Food intake, g/24 h | 2.73 ± 0.12 | 3.09 ± 0.12 | 3.03 ± 0.24 |
| Drinking volume, ml/24 h | 9.42 ± 1.00 | 7.40 ± 0.76 | 7.79 ± 0.56 |
| Urinary volume, ml/24 h | 5.34 ± 0.58* | 3.44 ± 0.52 | 3.94 ± 0.38 |
| Urinary osmolarity, mOsmol/l | 843.1 ± 78.1 | 1449.0 ± 223.8 | 1414.0 ± 181.0 |
| Plasma K+, mmol/l | 2.20 ± 0.08†§ | 3.89 ± 0.11 | 4.26 ± 0.16 |
| Urine K+, mmol/24 h | 0.02 ± 0.003*§ | 0.48 ± 0.051 | 1.54 ± 0.165† |
| K+ clearance, ml/24 h | 10.5 ± 1.1*§ | 123.2 ± 11.9 | 362.2 ± 39.3† |
| Plasma Cl−, mmol l−1 | 124.6 ± 3.4 | 131.1 ± 5.8 | 122.9 ± 4.5 |
| Urine Cl−, mmol/24 h | 1.19 ± 0.12 | 1.63 ± 0.18 | 1.33 ± 0.13 |
| Cl− clearance, ml/24 h | 10.3 ± 0.9 | 13.2 ± 1.9 | 10.7 ± 0.8 |
| Plasma Na+, mmol l−1 | 150.0 ± 1.3†‡ | 140.9 ± 1.7 | 142.6 ± 1.3 |
| Urine Na+, mmol/24 h | 1.46 ± 0.16* | 2.16 ± 0.22 | 1.49 ± 0.11* |
| Na+ clearance, ml/24 h | 10.5 ± 0.9* | 15.7 ± 1.6 | 10.5 ± 0.9* |
Mice were placed in metabolic cages for 24 h at the end of the 10 days of experimental diet. Plasma was taken at the end of the experimental period. Values represent mean ± s.e.m (n = 8 animals in each group).
*
P < 0.05
†
P < 0.001 versus normal K+ group
‡
P < 0.05
§
P < 0.001 versus high K+ group evaluated by one-way ANOVA followed by Bonferroni's multiple comparison tests.