Table 2.

Effect of mineralocorticoid receptor (MR) antagonism on plasma K⁺ and Na⁺ concentrations

		Plasma K+ concentration, mmol l−1		Plasma Na+ concentration, mmol l−1
Diet	n	Spironolactone treatment	Sham treatment	Spironolactone treatment	Sham treatment
0.03% K+, 3% Na+	7	2.63 ± 0.11	2.54 ± 0.07	153.0 ± 1.7	152.9 ± 0.5
5% K+, 3% Na+	8	5.69 ± 0.12*	4.70 ± 0.23	149.3 ± 1.2	150.4 ± 1.1

Plasma K⁺ and Na⁺ concentrations in mice fed a 10-day diet with or without spironolactone treatment (175 mg kg⁻¹ per day). Values represent mean ± s.e.m

^*(P < 0.01, Student's t test).