Figure 6.
Cumulative concentration-response curves to acetylcholine (Ach) of aorta rings preconcentrated with 10−5 M methoxamine from 20- (a) to 24-week-old (b) spontaneously hypertensive rats. The animals had received (from weaning until the 20th week of life) different daily treatments: tap water, 20 mg/kg/day Fraxinus excelsior L. seed extract (FESE), 40 mg/kg/day FESE, 60 mg/kg/day FESE, or 50 mg/kg/day captopril. All rats drank tap water from the 20th week of life until the 24th week of life (follow-up period). Data are mean values ± SEM for a minimum of 8 experiments. Similar letters represent no statistical differences (P > 0.05). P estimated by one-way ANOVA.