Figure 4.

Dependence of Avicel-induced genes on functional ClrB in A. nidulans. (A) K-means clusters of Avicel-induced genes in an A. nidulans ΔclrB mutant strain on Avicel as compared to a WT strain on Avicel or media with no carbon source. Heat map displays log (FPKM) scaled from minimal expression (bright blue) to the maximal expression (bright yellow). (B) Total expression of genes encoding major CAZy classes in the ΔclrB mutant on Avicel as compared to a WT strain on Avicel or media with no carbon source. Note the absence of expression of genes encoding predicted cellulases in the ΔclrB mutant (PMO, GH6, GH7, and GH5.5 classes, shown in blue).