Table 3. TGF-β and HIF-1α expressions and Clinicopathologic characteristics.
| Characteristics | TGF-β | HIF-1α | ||||
| Low | High | P a | Low | High | P a | |
| 265(59.4) | 181(40.6) | 229(51.3) | 217(48.7) | |||
| Age | ||||||
| <60 | 135(60.3) | 89(39.7) | 0.713 | 124(55.4) | 100(44.6) | 0.089 |
| ≥60 | 130(58.6) | 92(41.4) | 105(47.3) | 117(52.7) | ||
| Gender | ||||||
| Male | 204(58.6) | 144(41.4) | 0.519 | 176(50.6) | 172(49.4) | 0.540 |
| Female | 61(62.2) | 37(37.8) | 53(54.1) | 45(45.9) | ||
| Borrmann type | ||||||
| I | 40(63.5) | 23(36.5) | 0.183 | 28(44.0) | 35(55.6) | 0.435 |
| II+III | 207(58.5) | 147(41.5) | 186(52.5) | 168(47.5) | ||
| IV | 14(56.0) | 11(44.0) | 14(56.0) | 11(44.0) | ||
| V | 4 (100.0) | 0 (0.0) | 1(25.0) | 3 (75.0) | ||
| Tumor Size | ||||||
| <5 cm | 125(64.8) | 68(35.2) | 0.044 | 98(50.8) | 95(49.2) | 0.834 |
| ≥5 cm | 140(55.3) | 113(44.7) | 131(51.8) | 122(48.2) | ||
| Tumor Histological Morphology | ||||||
| Adenocarcinoma | 175(61.0) | 112(39.0) | 0.644 | 156(54.4) | 131(45.6) | 0.230 |
| Absolute signet ring cell carcinoma | 41(57.7) | 30(42.3) | 33(46.5) | 38(53.5) | ||
| Mixed carcinoma | 49(55.7) | 39(44.3) | 40(45.5) | 48(54.5) | ||
| Lauren type | ||||||
| Intestinal | 125(61.0) | 80(39.0) | 0.366 | 107(52.2) | 98(47.8) | 0.854 |
| Diffuse | 115(56.4) | 89(43.6) | 102(50.0) | 102(50.0) | ||
| mixed type | 25(67.6) | 12(32.4) | 20(54.1) | 17(45.9) | ||
| Tumor differentiation | ||||||
| Poor | 209(59.0) | 145(41.0) | 0.750 | 183(51.7) | 171(48.3) | 0.772 |
| Moderate and High | 56(60.9) | 36(39.1) | 46(50.0) | 46(50.0) | ||
| Vessel invasion | ||||||
| Yes | 160(57.3) | 119(42.7) | 0.250 | 142(50.9) | 137(49.1) | 0.806 |
| No | 105(62.9) | 62(37.1) | 87(52.1) | 80(47.9) | ||
| Perineural invasion | ||||||
| Yes | 181(57.8) | 132(42.2) | 0.294 | 166(53.0) | 147(47.0) | 0.273 |
| No | 84(63.2) | 49(36.8) | 63(47.4) | 70(52.6) | ||
| T category | ||||||
| T1 | 12(70.6) | 5(29.4) | 0.630 | 8(47.1) | 9(52.9) | 0.112 |
| T2 | 18(56.3) | 14(43.8) | 15(46.9) | 17(53.1) | ||
| T3 | 36(54.5) | 30(45.5) | 43(65.2) | 23(34.8) | ||
| T4 | 199(60.1) | 132(39.9) | 163(49.2) | 168(50.8) | ||
| N category | ||||||
| N0 | 65(67.0) | 32(33.0) | 0.069 | 53(54.6) | 44(45.4) | 0.147 |
| N1 | 47(50.0) | 47(50.0) | 46(48.9) | 48(51.1) | ||
| N2 | 61(56.0) | 48(44.0) | 47(43.1) | 62(56.9) | ||
| N3 | 92(63.0) | 54(37.0) | 83(56.8) | 63(43.2) | ||
| TNM stage | ||||||
| IA+IB | 20(74.1) | 7(25.9) | 0.005 | 15(55.6) | 12(44.4) | 0.775 |
| IIA | 15(68.2) | 7(31.8) | 13(59.1) | 9(40.9) | ||
| IIB | 50(60.2) | 33(39.8) | 43(51.8) | 40(48.2) | ||
| IIIA | 35(42.2) | 48(57.8) | 37(44.6) | 46(55.4) | ||
| IIIB | 61(57.5) | 45(42.5) | 54(50.9) | 52(49.1) | ||
| IIIC | 84(67.2) | 41(32.8) | 67(53.6) | 58(46.4) | ||
| Hepatic metastases | ||||||
| No | 219(61.2) | 139(38.8) | 0.128 | 204(57.0) | 154(43.0) | 0.000 |
| Yes | 46(52.3) | 42(47.7) | 25(28.4) | 63(71.6) | ||
| Peritoneum cavity metastasis | ||||||
| No | 201(63.6) | 115(36.4) | 0.005 | 180(57.0) | 136(43.0) | 0.000 |
| Yes | 64(49.2) | 66(50.8) | 49(37.7) | 81(62.3) | ||
a
Pearson's Chi-Square test or Fisher's Exact test, P<0.05.