Table 4. VEGF and pERK expressions and Clinicopathologic characteristics.
| Characteristics | VEGF | pERK | ||||
| Low | High | P a | Low | High | P a | |
| 252(56.5) | 194(43.5) | 297(65.7) | 149(34.3) | |||
| Age | ||||||
| <60 | 120(53.6) | 104(46.4) | 0.210 | 147(65.6) | 77(34.4) | 0.664 |
| ≥60 | 132(59.5) | 90(40.5) | 150(67.6) | 72(32.4) | ||
| Gender | ||||||
| Male | 192(55.2) | 156(44.8) | 0.286 | 236(67.8) | 112(32.2) | 0.302 |
| Female | 60(61.2) | 38(38.8) | 61(62.2) | 37(37.8) | ||
| Borrmann type | ||||||
| I | 39(61.9) | 24(38.1) | 0.642 | 36(57.1) | 27(42.9) | 0.090 |
| II+III | 195(55.1) | 159(44.9) | 238(67.2) | 116(32.8) | ||
| IV | 16(64.0) | 9(36.0) | 21(84.0) | 4(16.0) | ||
| V | 2 (50.0) | 2 (50.0) | 2(50.0) | 2 (50.0) | ||
| Tumor Size | ||||||
| <5 cm | 113(58.5) | 80(41.5) | 0.446 | 135(69.9) | 58(30.1) | 0.189 |
| ≥5 cm | 139(54.9) | 114(45.1) | 162(64.0) | 91(36.0) | ||
| Tumor Histological Morphology | ||||||
| Adenocarcinoma | 153(53.3) | 134(46.7) | 0.001 | 191(66.6) | 96(33.4) | 0.903 |
| Absolute signet ring cell carcinoma | 54(76.1) | 17(23.9) | 46(64.8) | 25(35.2) | ||
| Mixed carcinoma | 45(51.1) | 43(48.9) | 60(68.2) | 28(31.8) | ||
| Lauren type | ||||||
| Intestinal | 109(53.2) | 96(46.8) | 0.400 | 134(65.4) | 71(34.6) | 0.822 |
| Diffuse | 122(59.8) | 82(40.2) | 137(67.2) | 67(32.8) | ||
| mixed type | 21(56.8) | 16(43.2) | 26(70.3) | 11(29.7) | ||
| Tumor differentiation | ||||||
| Poor | 202(57.1) | 152(42.9) | 0.640 | 238(67.2) | 116(32.8) | 0.574 |
| Moderate and High | 50(54.3) | 42(45.7) | 59(64.1) | 33(35.9) | ||
| Vessel invasion | ||||||
| Yes | 167(59.9) | 112(40.1) | 0.065 | 187(67.0 | 92(33.0) | 0.802 |
| No | 85(50.9) | 82(49.1) | 110(65.9) | 57(34.1) | ||
| Perineural invasion | ||||||
| Yes | 184(58.8) | 129(41.2) | 0.136 | 208(66.5) | 105(33.5) | 0.924 |
| No | 68(51.1) | 65(48.9) | 89(66.9) | 44(33.1) | ||
| T category | ||||||
| T1 | 12(70.6) | 5(29.4) | 0.471 | 10(58.2) | 7(41.2) | 0.293 |
| T2 | 20(62.5) | 12(37.5) | 17(53.1) | 15(46.9) | ||
| T3 | 34(51.5) | 32(48.5) | 43(65.2) | 23(34.8) | ||
| T4 | 186(56.2) | 145(42.8) | 227(68.6) | 104(31.4) | ||
| N category | ||||||
| N0 | 64(66.0) | 33(34.0) | 0.091 | 66(68.0) | 31(32.0) | 0.619 |
| N1 | 51(54.3) | 43(45.7) | 61(64.9) | 33(35.1) | ||
| N2 | 64(58.7) | 45(41.3) | 68(62.4) | 41(37.6) | ||
| N3 | 73(50.0) | 73(50.0) | 102(69.9) | 44(30.1) | ||
| TNM stage | ||||||
| IA+IB | 20(74.1) | 7(25.9) | 0.240 | 14(50.0) | 13(50.0) | 0.540 |
| IIA | 13(59.1) | 9(40.9) | 14(50.0) | 8(50.0) | ||
| IIB | 50(60.2) | 33(39.8) | 56(67.8) | 27(32.2) | ||
| IIIA | 50(60.2) | 33(39.8) | 59(69.4) | 24(30.6) | ||
| IIIB | 55(51.9) | 51(48.1) | 68(65.3) | 38(34.7) | ||
| IIIC | 64(41.2) | 61(48.8) | 86(67.2) | 39(32.8) | ||
| Hepatic metastases | ||||||
| No | 206(57.5) | 152(42.5) | 0.372 | 240(67.0) | 118(33.0) | 0.686 |
| Yes | 46(52.3) | 42(47.7) | 57(64.8) | 31(35.2) | ||
| Peritoneum cavity metastasis | ||||||
| No | 174(55.1) | 142(44.9) | 0.339 | 218(69.0) | 98(31.0) | 0.094 |
| Yes | 78(60.0) | 58(40.0) | 79(60.8) | 51(39.2) | ||
a
Pearson's Chi-Square test or Fisher's Exact test, P<0.05.