Table 5. Multivariate analysis of significant prognostic factors for survival in patients with gastric carcinoma.
| Variables | DFS | OS | ||||
| P * | HR | 95%CI | P * | HR | 95%CI | |
| Age(<60years, ≥60years) | 0.968 | 1.005 | 0.787–1.283 | 0.676 | 1.058 | 0.813–1.376 |
| Borrmann type(I, II+III, IV, V) | 0.000 | 1.671 | 1.306–2.138 | 0.000 | 1.950 | 1.475–2.578 |
| Tumor Size(<5 cm, ≥5 cm) | 0.311 | 1.138 | 0.886–1.463 | 0.706 | 1.052 | 0.808–1.369 |
| Histological Morphology(A, S, M)1 | 0.481 | 1.036 | 0.939–1.143 | 0.505 | 1.305 | 0.935–1.146 |
| Lauren type(I, D, M)2 | 0.259 | 1.109 | 0.927–1.327 | 0.226 | 1.124 | 0.930–1.360 |
| Tumor differentiation(P/D, M/D+H/D)3 | 0.894 | 0.978 | 0.702–1.362 | 0.437 | 0.866 | 0.602–1.245 |
| Vessel invasion(YES, NO) | 0.239 | 1.157 | 0.908–1.475 | 0.152 | 1.201 | 0.935–1.544 |
| Perineural invasion(YES, NO) | 0.661 | 1.060 | 0.816–1.377 | 0.871 | 1.016 | 0.836–1.235 |
| T category(T1, T2, T3, T4) | 0.444 | 1.103 | 0.858–1.420 | 0.723 | 1.051 | 0.798–1.384 |
| N category(N0, N1, N2, N3) | 0.219 | 1.382 | 0.825–2.313 | 0.314 | 1.336 | 0.760–2.347 |
| TNM stage(I, II, IIIA, IIIB, IIIC) | 0.000 | 2.008 | 1.781–2.265 | 0.000 | 1.654 | 1.522–1.798 |
| Adjuvant chemotherapy(YES, NO) | 0.000 | 0.346 | 0.268–0.447 | 0.000 | 0.330 | 0.252–0.432 |
| TGF-β expression(W, O)4 | 0.143 | 1.191 | 0.943–1.506 | 0.319 | 1.136 | 0.884–1.460 |
| HIF-1α expression(W, O)4 | 0.000 | 2.766 | 2.136–2.583 | 0.000 | 3.529 | 2.663–4.667 |
| pERK1/2 expression(W, O)4 | 0.084 | 1.249 | 0.971–1.606 | 0.009 | 1.420 | 1.092–1.845 |
DFS, Disease-free survival; OS, Overall Survival; HR, hazard ratio; CI, Confidence interval; *P<0.05; 1, A, Adenocarcinoma, S, Absolute signet ring cell carcinoma, M, Mixed carcinoma; 2, I, Intestinal, D, Diffuse, M, Mixed type; 3, P/D, Poor differentiation, M/D, Moderate differentiation, H/D High differentiation; 4, W, Weak-expression, O, Overexpression.