Table 3.

Sensitivity and Specificity of Individual MDASI Items and the Depressed-Mood Component Score at Various Cut Points for Assessing Depressed Mood

Assessment	Moderate-to-Severe Depressive Symptoms*
	Specificity (%)	Sensitivity (%)
	Individual Item Score ≥4
Single item
Cohort 1
Sadness	81.5	72.0
Distress	78.4	56.0
Interference with enjoyment of life	66.5	76.0
Interference with mood	78.4	68.0
Cohort 2
Sadness	91.0	68.0
Distress	89.5	72.0
Interference with enjoyment of life	85.9	64.0
Interference with mood	87.4	72.0
	Component Score ≥19
Multiple item
Depressed-mood component score†
Cohort 1	83.0	84.0
Cohort 2	88.9	76.0

Abbreviations: BDI-II, Beck Depression Inventory-II; CES-D, Center for Epidemiologic Studies Depression Scale; MDASI, MD Anderson Symptom Inventory.

^*For cohort 1, BDI-II score ≥ 20 = moderate-to-severe depressed mood; for cohort 2, CES-D score ≥ 27 = moderate-to-severe depressed mood.

^†Depressed-mood component score = sum score of MDASI items: sadness, fatigue, interference with mood, relations with others, and enjoyment of life.