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. 2014 Feb 25;8:15–38. doi: 10.4137/BCBCR.S13833

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© 2014 the author(s), publisher and licensee Libertas Academica Ltd.

This is an open-access article distributed under the terms of the Creative Commons CC-BY-NC 3.0 License.

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A–K Mammographically detected architectural distortion in the upper-outer quadrant of the right breast with no associated microcalcifications. There is also a pathologic lymph node in the right axilla (A,B). Microfocus magnification (C) and breast MRI (D) demonstrate the large extent of the disease. Specimen slice radiographs (E,G) compared with large thin-section (F) and large thick-section histology (H) images show the cancer-filled, tortuous, newly formed ducts tightly packed together. Low power histology images (I,J,K) demonstrate that the abnormal, cancer-filled, duct-like structures with micropapillary cell architecture are surrounded by a thick desmoplastic reaction and lymphocytic infiltration, which are the histologic signs of neoductgenesis.

A–K Mammographically detected architectural distortion in the upper-outer quadrant of the right breast with no associated microcalcifications. There is also a pathologic lymph node in the right axilla (A,B). Microfocus magnification (C) and breast MRI (D) demonstrate the large extent of the disease. Specimen slice radiographs (E,G) compared with large thin-section (F) and large thick-section histology (H) images show the cancer-filled, tortuous, newly formed ducts tightly packed together. Low power histology images (I,J,K) demonstrate that the abnormal, cancer-filled, duct-like structures with micropapillary cell architecture are surrounded by a thick desmoplastic reaction and lymphocytic infiltration, which are the histologic signs of neoductgenesis.