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. 2014 Feb 25;8:15–38. doi: 10.4137/BCBCR.S13833

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© 2014 the author(s), publisher and licensee Libertas Academica Ltd.

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(A) A solitary cluster of crushed stone-like (pleomorphic) calcifications was detected at mammography screening. (B) Ultrasound examination: a 12-mm solitary hypoechogenic area with calcifications, corresponding to a distended TDLU. (C) Microfocus magnification specimen radiograph: malignant-type calcifications in a cluster. (D) Low power large section histology image of the solitary TDLU, distended and distorted by the Grade 2 in situ carcinoma. (E) Higher power magnification of a single acinus: solid and cribriform cancer in situ with central necrosis and amorphous calcification distending the acinus. Histologic diagnosis: Grade 2 in situ carcinoma within the TDLU (unifocal AAB).