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. 2014 Mar 10;9(3):e91257. doi: 10.1371/journal.pone.0091257

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© 2014 Tamaki et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Tissues having strong GFP emission actively encircled single or multiple axons stained by N-200, thus suggesting formation of perineurium and endoneurium in the Sk-MSC-7d group. This was a common trend in the Sk-MSC-transplanted groups throughout the experiment. (B) GFP⁺ circles (probably perineurium/endoneurium) also enclosed single/multiple myelin sheaths stained by MBP. (D) Some showed double positive staining for BMP and GFP, thus suggesting donor cell-derived myelin formation (arrows in D). (C) Several claudin⁺ reactions were located on donor-derived GFP⁺ perineurium (arrows in C), demonstrating the formation of tight-junctions. (E) Incorporation of GFP⁺/CD31⁺ cells into blood vessels inside the nerve bundle (arrows in E). Incorporation was seen frequently, but not in all cases. (F) Similar contributions were observed in the large conduit blood vessels located outside of nerve bundles (arrows in F), and GFP⁺ donor cell contributions extended from the tunica media to the adventitia in this case. All scale bars represent 50 µm.