Table 3. Most significant associations between polymorphisms in biogenesis machinery and toxicity parameters.

Gene	SNP	Toxicity	Phase	Genotype	No toxicity, n (%)	Toxicity, n (%)	OR (95% CI)	p-value	p-corrected
DROSHA	rs639174	Vomits	Cons	CC	47 (92.2)	4 (7.8)	1.00	0.0003	0.0276
				CT/TT	43 (65.2)	23 (34.9)	6.28 (2.01–19.64)
	rs2287584	Vomits	Cons	TT	54 (88.5)	7 (11.5)	1.00	0.0026	0.1196
				CT/CC	41 (66.1)	21 (33.9)	3.95 (1.53–10.18)
	rs10035440	Hyperbilirubinemia	Ind	TT	43 (72.9)	16 (27.1)	1.00	0.0041	0.1886
				CT/CC	65 (92.9)	5 (7.1)	0.23 (0.08–0.68)
	rs4867329	Vomits	Cons	AA/AC	74 (72.6)	28 (27.5)	1.00	0.0088	0.2162
				CC	21 (95.5)	1 (4.6)	0.13 (0.02–0.98)
	rs3805500	Hepatic toxicity	Cons	AA/AG	70 (68.0)	33 (32.0)	1.00	0.0091	0.2392
				GG	17 (94.4)	1 (5.6)	0.12 (0.02–0.98)
XPO5	rs34324334	Hyperbilirubinemia	Ind	CC	101 (88.6)	13 (11.4)	1.00	0.0011	0.1012
				CT	7 (50.0)	7 (50.0)	7.77 (2.35–25.7)
TNRC6A	rs6497759	Hepatic toxicity	Ind	GG	63 (76.8)	19 (23.2)	1.00	0.0013	0.1196
				AG/AA	23 (48.9)	24 (51.1)	3.46 (1.60–7.46)
TNRC6B	rs9611280	Hepatic toxicity	Cons	GG	70 (67.3)	34 (32.7)	1.00	0.0042	0.2392
				AG	19 (95.0)	1 (5.0)	0.11 (0.01–0.84)
CNOT1	rs11866002	Mucositis	Ind	CC/CT	98 (81.7)	22 (18.3)	1.00	0.0056	0.3956
				TT	4 (40.0)	6 (60.0)	6.68 (1.74–25.70)
DDX20	rs197388	Renal toxicity	Ind	AA/AT	121 (97.6)	3 (2.4)	1.00	0.0068	0.4048
				TT	3 (60.0)	2 (40.0)	26.89 (3.21–225)
GEMIN4	rs3744741	Hepatic toxicity	Ind	CC	70 (73.7)	25 (26.3)	1.00	0.0080	0.2392
				CT/TT	17 (48.6)	18 (51.4)	2.96 (1.33–6.63)
EIF2C1	rs595961	Vomits	Ind	AA	67 (79.8)	17 (20.2)	1.00	0.0086	0.4017
				AG/GG	24 (57.1)	18 (42.9)	2.96 (1.31–6.65)

Ind: induction. Cons: consolidation.

p-corrected =  p-value after FDR correction.

N.S.: non-significant, p-value>0.05 after FDR correction.