Table 4. Most significant associations between polymorphisms in pre-miRNAs and toxicity parameters.
| Gene | SNP | Toxicity | Phase | Genotype | No toxicity, n(%) | Toxicity, n(%) | OR (95% CI) | p-value | p-corrected |
| mir-300 | rs12894467 | Hepatic toxicity | Ind | CC/CT | 82 (71.9) | 32 (28.1) | 1.00 | 0.0038 | 0.1748 |
| TT | 5 (33.3) | 10 (66.8) | 5.12 (1.63–16.16) | ||||||
| Hyperbilirubinemia | Ind | CC/CT | 99 (86.8) | 15 (13.2) | 1.00 | 0.0174 | 0.2990 | ||
| TT | 9 (60.0) | 6 (40.0) | 4.40 (1.37–14.13) | ||||||
| mir-449b | rs10061133 | Renal toxicity | Ind | AA | 111 (98.2) | 2 (1.8) | 1.00 | 0.0132 | 0.4048 |
| GA/GG | 15 (83.3) | 3 (16.7) | 11.10 (1.71–71.9) | ||||||
| mir-453 | rs56103835 | Vomits | Cons | AA | 66 (83.5) | 13 (16.5) | 1.00 | 0.0141 | 0.2162 |
| GA/GG | 28 (63.6) | 16 (36.4) | 2.90 (1.23–6.82) | ||||||
| MTX clearance | Cons | AA | 62 (72.1) | 24 (27.9) | 1.00 | 0.0297 | 0.4554 | ||
| GA/GG | 25 (53.2) | 22 (46.8) | 2.27 (1.08–4.77) | ||||||
| mir-2053 | rs10505168 | Mucositis | Cons | TT | 43 (82.7) | 9 (17.3) | 1.00 | 0.0154 | 0.4298 |
| CT/CC | 68 (95.8) | 3 (4.2) | 0.21 (0.05–0.82) | ||||||
| mir-423 | rs6505162 | Diarrhea | Ind | CC | 25 (75.8) | 8 (24.2) | 1.00 | 0.0240 | 0.4618 |
| AC/AA | 88 (91.7) | 8 (8.3) | 0.28 (0.10–0.83) | ||||||
| mir-1307 | rs7911488 | Diarrhea | Ind | AA/AG | 100 (90.1) | 11 (9.9) | 1.00 | 0.0241 | 0.4618 |
| GG | 10 (66.7) | 5 (33.3) | 4.55 (1.31–15.72) | ||||||
| mir-618 | rs2682818 | Hyperbilirubinemia | Ind | CC/AC | 110 (85.4) | 19 (14.7) | 1.00 | 0.0247 | 0.3002 |
| AA | 0 (0.0) | 2 (100.0) | NE (NE- NE) | ||||||
| mir-146a | rs2910164 | Diarrhea | Ind | GG | 70 (93.3) | 5 (6.7) | 1.00 | 0.0251 | 0.4618 |
| CG/CC | 45 (80.4) | 11 (19.6) | 3.42 (1.11–10.50) | ||||||
| mir-1206 | rs2114358 | Mucositis | Cons | AA/AG | 96 (92.3) | 8 (7.7) | 1.00 | 0.0254 | 0.4298 |
| GG | 15 (75.0) | 5 (25.0) | 4.57 (1.28–16.28) | ||||||
| mir-577 | rs34115976 | Hyperbilirubinemia | Ind | CC | 67 (78.8) | 18 (21.2) | 1.00 | 0.0261 | 0.3002 |
| CG/GG | 41 (93.2) | 3 (6.8) | 0.27 (0.08–0.98) | ||||||
| mir-604 | rs2368393 | Renal toxicity | Cons | AA | 65 (95.6) | 3 (4.4) | 1.00 | 0.0271 | 0.6866 |
| AG/GG | 47 (83.9) | 9 (16.1) | 4.15 (1.07–16.15) | ||||||
| mir-492 | rs2289030 | Vomits | Ind | GG | 90 (76.3) | 28 (23.7) | 1.00 | 0.0282 | 0.5188 |
| CG | 6 (46.2) | 7 (53.9) | 3.75(1.16–12.08) |
Ind: induction. Cons: consolidation.
p-corrected = p-value after FDR correction.
N.S.: non-significant, p-value>0.05 after FDR correction.