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. 2014 Jan 6;196(3):781–797. doi: 10.1534/genetics.113.160945

Figure 2.

Figure 2

Conserved binding motifs in Drosophila, human, and locust neprilysins. (A) Schematic representation of neprilysin. Solid, cytoplasmic domain; light shading, transmembrane domain; dark shading, extracellular domain. NAYY/F, important for substrate binding; HExxH, zinc-binding domain; ExxxD, zinc-binding domain; CxxW: sequence critical for protein folding and maturation of the enzyme. (B) Alignment of NAY/FY, HExxH, ExxxD, and CxxW sequences of D. melanogaster Nep1-5, L. migratoria ECE, and H. sapiens ECE1-2.