Fig. 1.

Epidermal growth factor receptor (EGFR) +/Dsk5 mice have enlarged livers. A: body weight (left) and liver weight (right) were determined in 12-wk-old male +/+ and +/Dsk5 mice. The liver weight is expressed as a percentage of total body weight. The +/Dsk5 mouse had a larger average body weight, but they were not significantly different (P < 0.09). In contrast, the liver weight was significantly increased in the +/Dsk5 mouse (P < 0.0002). B: livers of +/+ and +/Dsk5 mice were removed at different ages and expressed as a percentage of total body weight. The livers in the +/Dsk5 mice 3 days after weaning (.875 mo) were larger but not statistically significantly different. The increase in liver weight in all other groups was statistically significantly different *P < 0.05.