Fig. 3.

Hepatocytes of +/Dsk5 mice have larger nuclei, larger cell volumes, and fewer binucleate cells. A: photomicrograph of sections of livers from 3-mo-old male mice stained with the Feulgen method to detect DNA. Note that the nuclei of the +/Dsk5 hepatocytes were larger and darker, and their cell diameters were larger than the +/+ hepatocytes. However, the latter had more binucleate cells. B: quantification of the relative nuclear (left) and cellular diameters (middle) and number of binucleate hepatocytes (right). *P < 0.0001.