Fig. 6.

Deletion of exon 11-encoded region of β- or γ-hENaC subunit results in a loss of function. Whole cell currents were measured in oocytes injected with αβγ (WT), αβΔExon11γ, or αβγΔExon11 cRNAs and clamped at −100 mV. Normalized currents for WT and mutant channels were obtained in the same way as in Fig. 2B. Both mutant values were significantly different from the WT value (P < 0.001). Data were collected in four batches of oocytes, and the numbers of cells for each group are shown in parentheses.