Table 2.
Physiological parameters of experimental groups after 14 days of treatment
| n | Sham + Vehicle | Sham + Clopidogrel | 60 ng/min ANG II + Vehicle | 60 ng/min ANG II + Clopidogrel | 70 ng/min ANG II + Clopidogrel | |
|---|---|---|---|---|---|---|
| Body weight, g | 24 | 354 ± 6 | 369 ± 7 | 326 ± 6* | 320 ± 6 | 336 ± 8* |
| Systolic blood pressure, mmHg | 24 | 118 ± 3 | 120 ± 3 | 198 ± 5* | 195 ± 4 | 195 ± 4* |
| Water intake, ml/day | 24 | 37.5 ± 4 | 38.3 ± 3 | 55.7 ± 4* | 55.3 ± 3* | 55.0 ± 5* |
| Urine volume, ml/day | 18 | 20.0 ± 1.9 | 20.1 ± 1.8 | 36.7 ± 3.0* | 38.9 ± 3 | 36.9 ± 3.9* |
| Bleeding time, s | 24 | 407 ± 24 | 1200 ± 0 | 304 ± 17 | 1120 ± 17 | 987 ± 81 |
| Anesthetized mean arterial pressure, mmHg | 6 | 131 ± 5 | 126 ± 3 | 162 ± 12* | 169 ± 3 | 165 ± 16* |
| Anesthetized renal blood flow, ml·min−1·g kidney mass−1 | 6 | 10.7 ± 0.9 | 9.1 ± 1.1 | 11.0 ± 1.0 | 9.7 ± 0.8 | 8.6 ± 1.6 |
Values are mean ± SE; n, number of total rats/group with a subset of the rats undergoing 24-h urine collection. Statistical analysis was not performed on bleeding time data because the variation on the measurement is not known. Bleeding was terminated deliberately using a silver nitrate styptic pencil in cases where bleeding time extended beyond a maximum of 1,200 s.
*
P < 0.05 vs. the respective sham group.