Fig. 5.
UcnII-induced nuclear export of NFATc1 in heart failure (HF). A: confocal images of subcellular NFATc1-GFP distribution in normal (a) and HF ventricular myocytes (b). Subcellular NFATc1-GFP distribution in HF ventricular myocytes in the presence of UcnII (c), UcnII + ALP (d), and UcnII + ODQ (e). B: average control RNFATc1 in normal and HF myocytes. *P < 0.001 vs. normal. C: average normalized RNFATc1 data from HF myocytes in control, UcnII, UcnII + ALP, and UcnII + ODQ. *P < 0.001 vs. UcnII. Scale bar = 20 μm.