Table 2.
Estrogen Loss (OVX) | Estrogen Loss and nNOS Inhibition | Estrogen Loss and BH4 Treatment | |
---|---|---|---|
Hypertension | ↑↑↑ | ↑↑ | ↑↑↑ |
BH4:BH2 | ↓ | ↓ | ↑ biopterins |
Cardiac ROS | ↑ | ↓ | ↓ |
Cardiac NO | ↓ | ↓ | ↑ |
Fibrosis | ↑ | ↓ | ↓ |
Diastolic function | Moderately reduced | Preserved | Preserved |