Table 2.
Baseline |
Dobutamine |
|||||
---|---|---|---|---|---|---|
Mouse | NMR | Significance | Mouse | NMR | Significance | |
Heart rate, beats/min | 461 ± 14 | 229 ± 10 | <0.0001 | 600 ± 16 | 306 ± 13 | <0.0001 |
Average diastolic wall thickness, mm | 0.77 ± 0.03 | 0.87 ± 0.02 | 0.0198 | 0.77 ± 0.03 | 0.88 ± 0.02 | 0.0152 |
LV end-diastolic dimension, mm | 3.67 ± 0.08 | 4.03 ± 0.24 | N.S. | 3.34 ± 0.09 | 3.74 ± 0.21 | N.S. |
LV end-systolic dimension, mm | 2.27 ± 0.12 | 2.93 ± 0.24 | 0.0239 | 1.66 ± 0.08 | 2.08 ± 0.18 | N.S. |
Fractional shortening, % | 39 ± 2 | 28 ± 2 | 0.0002 | 52 ± 2 | 46 ± 2 | 0.0345 |
Ejection fraction, % | 57 ± 3 | 43 ± 2 | 0.0008 | 79 ± 1 | 75 ± 2 | N.S. |
Cardiac output, ml/min | 14.9 ± 0.7 | 6.5 ± 0.4 | <0.0001 | 21.7 ± 0.9 | 11.5 ± 1.1 | <0.0001 |
Stroke volume, μl | 34.4 ± 1.4 | 26.0 ± 1.4 | 0.001 | 34.9 ± 1.3 | 37.2 ± 3.6 | N.S. |
All values are means ± SE. LV, left ventricular. Sample sizes are n = 10 (5/sex) animals for each species. Significance is indicated by P values; N.S. denotes P > 0.05.