Fig. 1.

Effect of RYGB surgery in high-fat diet-induced obese rats on body weight and body composition. A: male Sprague-Dawley rats were maintained on a high-fat diet throughout the study, and body composition was assessed before and after surgery. In addition, an age-matched, nonsurgical control group was fed regular low-fat chow throughout. Body weight of RYGB rats rapidly decreased within the first 2 wk and remained at that reduced level throughout the observation period, closely matching body weight of chow-fed controls. B–E: effects of RYGB on total fat mass (B), relative fat mass (adiposity; C), total lean mass (D), and relative lean mass (E) in sham-operated (light gray bars), RYGB rats (dark gray bars), and chow-fed, unoperated, age-matched lean controls (open bars). Note that RYGB completely reversed excess high-fat diet-induced fat mass, and lean mass gain to levels found in chow-fed rats. Values are expressed as means ± SE of 15–20 rats/group. Bars that do not share the same letters denote significant differences at P < 0.05 (based on ANOVA followed by Bonferroni-adjusted multiple comparisons).