Table 1.

Fold changes of the reporter gene activities in ARPE-19 cells in response to oxLDL alone or combined with E3330.

Transcription factor	Reporter gene activity fold change						Pathway
	oxLDL/Control	p Value	oxLDL+E3330/oxLDL	p Value	oxLDL+E3330/Control	p Value
Nrf2/Nrf1	1.71	0.008	0.60	0.003	0.84	0.409	Antioxidant response
p53	1.70	0.001	0.59	0.000	0.82	0.130	DNA damage
NFκB	1.76	0.008	0.58	0.011	1.04	0.850	NFκB
HIF-1	1.65	0.012	0.63	0.021	1.08	0.658	Hypoxia
CBF/NF-Y/YY1	2.33	0.002	0.44	0.004	1.16	0.549	ER stress
MTF1	1.26	0.043	0.80	0.042	1.00	0.980	Heavy metal stress
HSF-1	1.59	0.000	0.63	0.002	1.22	0.024	Heat shock
Glucocorticoid Receptor (GR)	1.49	0.015	0.68	0.312	1.33	0.065	Glucocorticoid
AP-1	1.43	0.039	0.71	0.113	1.13	0.465	MAPK/JNK
AhR	1.65	0.004	0.61	0.094	1.36	0.047	Xenobiotic

OxLDL versus Con, 150 μg/mL oxLDL challenge versus vehicle control.

OxLDL+E3330 versus oxLDL, concomitant treatment of 150 μg/mL oxLDL plus 30 μM E3330 versus 150 μg/mL oxLDL challenge.

OxLDL+E3330 versus Con, concomitant treatment of 150 μg/mL oxLDL plus 30 μM E3330 versus vehicle control.