Table 3.

Impact of rosiglitazone on the mRNA expression and protein abundance of factors regulating glucose uptake in heart muscle in late gestation

	Control	Rosiglitazone
Gene expression (MNE)
GLUT-1	0.050 ± 0.002	0.051 ± 0.006
GLUT-4	0.14 ± 0.02	0.13 ± 0.01
Protein abundance, AU × 102
IRβ	848 ± 91	572 ± 44*
IRS-1	384 ± 63	239 ± 23*
phospho-IRS-1 (Tyr895)	1,018 ± 57	860 ± 88*
PI3K (p85)	199 ± 9	158 ± 11*
PI3K (p110α)	456 ± 9	355 ± 32*
PDPK-1	628 ± 93	475 ± 65
phospho-PDPK-1 (Ser241)	301 ± 29	207 ± 23*
Akt1	253 ± 25	169 ± 21*
phospho-Akt (Ser273)	1,818 ± 228	234 ± 55***
PKCζ	1,004 ± 101	696 ± 72*
phospho-PKCζ (Thr410)	952 ± 106	337 ± 71**
AS160	216 ± 38	105 ± 19*
phospho-AS160 (Thr642)	253 ± 9	76 ± 30**
GLUT-4	245 ± 17	185 ± 18*
GLUT-1	50 ± 8	76 ± 6*

Data are presented as means ± SE. MNE, mean normalized expression; AU, arbitrary units.

^*P < 0.05,

^**P < 0.01,

^***P < 0.001.