Table 5.

Impact of rosiglitazone on the mRNA expression and protein abundance of factors regulating proliferation and hypertrophy and markers of hypertrophy in heart muscle in late gestation

	Control	Rosiglitazone
Gene expression (MNE)
IGF-1	0.12 ± 0.01	0.09 ± 0.02
IGF-2	12.0 ± 1.4	13.3 ± 1.6
IGF-1R	0.58 ± 0.05	0.57 ± 0.04
IGF-2R	1.8 ± 0.1	1.8 ± 0.2
p27	0.31 ± 0.06	0.30 ± 0.02
Cyclin D1	0.021 ± 0.003	0.018 ± 0.003
CDK-4	0.18 ± 0.04	0.16 ± 0.03
c-myc	0.23 ± 0.03	0.23 ± 0.03
ANP	0.32 ± 0.09	0.27 ± 0.07
Protein abundance, AU × 102
IGF-1R	540 ± 74	377 ± 48
IGF-2R	529 ± 14	565 ± 76
ANP	167 ± 18	161 ± 10

Data are presented as means ± SE.