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Schematic Ig synthesis pathway. Naïve B-cells are classically recruited in lymphoid organs where they undergo somatic hypermutation, proliferate, and recirculate as short-lived plasmablasts (PB). PB migrate to bone marrow, differentiate to long-lived plasma cells (PC), and synthesize the bulk of plasmatic IgG. However, secondary/tertiary lymphoid organs may also retain PC in survival niches, where they participate in IgG synthesis.
