Table 1.
Calculated mean ± standard deviation non-compartmental pharmacokinetic parameters for serum suberoylanilidehydroxamic acid (SAHA) concentration data after IV and PO administration to adult cats (n=6). Doses and administration routes were 2 mg/kg intravenous (IV) SAHA (solvated at 20 mg/mL in DMSO) or 250 mg/m2 oral (PO) SAHA in gelatin capsules.
| Parameter | IV | PO |
|---|---|---|
| Dose | 2 mg/kg | 250 mg/m2 = 17±2 mg/kg |
| T1/2λz (hr) | 0.15 ± 0.03 | 2 ±1 |
| Clobs (mL/hr/kg) | 14,000 ± 5,000 | - |
| VDss,obs (mL/kg) | 1600 ± 800 | - |
| Cmaxobs (ng/mL) | - | 40 ± 10 |
| Tmaxobs (hr) | - | 0.6 ± 0.3 |
| AUC0 → τ (hr*ng/mL) | 150 ± 40 | 70 ± 10 |
| AUC0 → ∞ (hr*ng/mL) | 150 ± 50 | 80 ± 20 |
| Percent Extrapolated (%) | 0.6 ± 0.2 | 17 ± 7 |
| F (%), n=5 | - | 8 ± 4 |
T1/2λz, elimination half-life, CLobs: Observed clearance, VDss,obs: Observed volume of distribution at steady state, Cmax(obs), observed maximum serum concentration; Tmax(obs), time to observed maximal serum concentration; AUC0 → τ area under the serum concentration vs. time curve to the last value; AUC0 → ∞ area under the serum concentration vs. time curve extrapolated to infinity; F(%): oral bioavailability