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. 2013 Nov 13;134(10):2330–2341. doi: 10.1002/ijc.28557

Figure 2.

Figure 2

RNA expression, genomic organization and promoter analyses of COLCA1 and COLCA2. (a) Relative mRNA expression levels of 11q23 transcripts in benign adjacent (BA) and tumor (T) samples as a function of the rs3802842 genotype. Error bars indicate SEM. p values are derived from one-way ANOVA followed by Student-Newman-Keuls test. *p<0.01, **p<0.001. (b) Genomic organization of C11orf92/COLCA1 (gold) and C11orf93/COLCA2 (blue). (c) Luciferase (LUC)-based reporter constructs for COLCA1 (top) and COLCA2 (bottom). Lower risk (LRH) and higher risk (HRH) haplotypes are depicted as blue and red bars, respectively. (d) Luminescence results in HeLa cells. Values are expressed as mean ± SEM for n = 3. *p < 0.05. V is a promoter-less luciferase vector; p#1–3 denote patients 1–3.