Table 1. Hematology and chemistry values in 4T1 bearing mice treated with MV-m-uPA*.
TEST | Treatment | Normal range | Units of Measure | |
---|---|---|---|---|
Ctrl (vehicle) | MV-m-uPA | |||
White Blood Cell Count | 16.37±3.27 | 24.57 ±7.40 | 4.5-9.1 | ×103/ul |
Red Blood Cell Count | 9.93±0.37 | 9.95±0.23 | 7.51-9.66 | ×106/ul |
Hemoglobin | 14.53±0.25 | 14.77±0.50 | 12.8-16.1 | g/dL |
Hematocrit | 46.67.±1.15 | 46±2.65 | 34-50 | % |
MCV | 46.67±0.58 | 46±1.73 | 41-60 | fL |
MCH | 14.67±0.58 | 14.67±0.58 | 13-19 | pg |
MCHC | 31.33±0.58 | 32.3±1.15 | 30-39 | % |
Segmented Neutrophis | 64±2.65 | 71.33±2.31 | 21-57 | % |
Band Neutrophils | 0±0 | 0±0 | 0-1 | % |
Lymphocytes | 32.67±3.06 | 23±3.61 | 49-82 | % |
Monocytes | 0.67±0.58 | 1.67±0.58 | 2-8 | % |
Eosinophils | 2.33±0.58 | 4±1 | 0-3 | % |
Basophils | 0.33±0.58 | 0 | 0-3 | % |
NRBC | 0±0 | 0 | ||
RBC Morphology | Normal | Normal | ||
Platelet Morphology | Normal | Normal | ||
WBC Morphology | Normal | Normal | ||
Hemolysis | 2 ±0 | 1.67±0.58 | 0 | |
Lipemia Index | 0±0 | 0±0 | 0 | |
Glucose | 161.67±54.24 | 145±55.82 | 90-193 | mg/dL |
BUN | 15.33±1.15 | 13.67.±1.52 | 18-29 | mg/dL |
CREA | 0.1±0 | 0.13±0.06 | 0.1-0.4 | mg/dL |
Calcium | 8.6±0.6 | 9.33±0.42 | 8.7-10.1 | mg/dL |
Phosphorus | 9.37±0.25 | 8.63±0.47 | 5.4-9.3 | mg/dL |
Total Protein | 5.2±0.1 | 5.4±0.53 | 4.6-6.9 | g/dL |
ALT | 99.67±10.01 | 54.67±13.2 | 29-191 | U/L |
4T1 tumor bearing Balb/c mice (n = 5) were given 2 doses of 1.5×106 MV-m-uPA or PBS via tail vein as described in the methods section At day 5, blood samples were obtained for complete blood count and clinical chemistry (liver and renal function) analysis using a Hemavet 1700 multispecies hematology analyzer and an Ortho Vitros 250 analyzer, respectively.