Table 4.

Serotonin transporter, 1A and 2A receptors by low- and high-expressing genotype groupings for significant drug effects. Highlighted pairs represent ‘pharmacogenetic effects’ where there is a significant difference in regression coefficients between the expression-based groupings for a side-effect.

UKU	5-HTTLPR triallelic haplotype		HTR1A rs6295		HTR2A rs6311
genotype (expression- level)	LA− (low)	LA+ (high)	CC (low)	GG/CG (high)	GG (low)	AA/AG (high)
n	49	102	35	116	53	97
Increased sleep β (SE)	.70 (.59)	1.32 (.47)	1.70 (.69)	1.12 (.47)	1.39 (.51)	1.10 (.53)
Dry mouth β (SE)	1.20 (.41)*	.17 (.30)*	.41 (.61)	.54 (.27)	.89 (.38)	.30 (.32)
Diarrhea β (SE)	.66 (.43)	.57 (.28)	1.37 (.45)*	.30 (.27)*	1.15 (.40)	.42 (.30)
Diminished Sexual Desire β (SE)	.16 (.55)*	2.39 (.73)*	1.09 (.76)*	1.58 (.64)*	.89 (.66)*	2.25 (.85)*

^*p<.05 between GEE regression coefficients for low- and high-expressing genotypes

A Z test was used to test for the equality of regression coefficients (30).