Table 1.
Participant characteristics
| Controls (n = 12) | DPN Patients (n = 12) | |
|---|---|---|
| Anthropometric parameters | ||
| Male/Female | 7/5 | 7/5 |
| Age, yr | 64.5 ± 14.7 | 65.6 ± 14.6 |
| Height, m | 1.8 ± 0.1 | 1.7 ± 0.1 |
| Weight, kg | 73.8 ± 6.1 | 83.1 ± 7.4* |
| BMI, kg/m2 | 24.4 ± 3.1 | 28.9 ± 3.7* |
| Diabetic characteristics | Range or limit of normal | |
| Duration of diabetes, yr | 14.1 ± 11.2 | |
| Duration of DPN, yr | 9.2 ± 8.1 | |
| HbA1c, % | <6.0 | 7.4 ± 1.4 |
| Triglycerides, mmol/l | 0.77–1.7 | 1.9 ± 1.3 |
| Cholesterol, mmol/l | 3.0–5.0 | 4.1 ± 0.3 |
| HDL cholesterol, mmol/l | 0.9–2.0 | 1.3 ± 0.5 |
| LDL cholesterol, mmol/l | 2.0–3.0 | 2.1 ± 0.8 |
| Total cholesterol:HDL ratio | <5.0 | 3.9 ± 0.9 |
| Nerve conduction studies | Range or limit of normal | |
| Sural nerve SNAP amplitude, μV | >5 | 1.3 ± 2.5# |
| TA CMAP amplitude, mV | >4.5 | 5.0 ± 1.7 |
| Fibular nerve CV, m/s | >40.0 | 41.4 ± 10.4 |
| FDI CMAP amplitude, mV | >10.0 | 10.3 ± 2.7 |
| Ulnar nerve CV, m/s | >53.0 | 49.2 ± 3.4 |
Values are means ± SD, unless otherwise indicated. HDL, high-density lipoprotein; LDL, low-density lipoprotein; DPN, diabetic polyneuropathy; BMI, body mass index; SNAP, sensory nerve action potential; TA, tibialis anterior; CMAP, compound muscle action potential; CV, conduction velocity.
*
Significant difference between groups (P < 0.05).
#
SNAP responses were absent in 10 of 12 patients.