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. 2014 Mar 11;8:11. doi: 10.3389/fnana.2014.00011

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Copyright © 2014 Gutzmann, Ergül, Grossmann, Schultz, Wahle and Engelhardt.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ankyrin-G as a reliable marker for AIS length analysis in cortical neurons. AIS were specifically stained using various markers. (A) AnkG (green) and NeuN (red) in layer II/III neurons in a P35 animal. (B) βIV spectrin (green) and NeuN (red) in layer II/III neurons in a P35 animal. (C) PanNa_V (red) in layer II/III neurons in a P15 animal. (D) Merged image of C and ankG (green) with TO-PRO^©-3 (blue) as nuclear stain, showing complete overlap of ankG and panNa_V signals. (E) Fluorescence intensity profile for AIS markers ankG (green) and βIV spectrin (red) in an example of a long AIS in a P15 animal, indicating signal overlap for the same AIS distance from the soma. (F) Fluorescence intensity profile for ankG (green) and panNa_V (red), here in an example of a short AIS (P15). Again, signals overlapped with both markers. Scale bars (A–D) = 20 μm.