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. 2014 Mar 11;4:4344. doi: 10.1038/srep04344

Figure 8. Mechanisms of action by which CAP-NO inhibits adhesion of CTCs to vascular endothelium.

Figure 8

CAP-NO makes direct vasorelaxation, increases blood flow, inhibits platelet activation and aggregation. As a result, CAP-NO interfered with the hetero-adhesion between CTCs and vascular endothelial cells by down-regulation of CAMs expression induced by cytokines. A series of beneficial effects of CAP-NO in preventing CTCs from adhesion, invasion to endothelial bed and the resultant micrometastatic foci may attribute to its collective actions.