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. 2014 Mar 14;20(10):2641–2652. doi: 10.3748/wjg.v20.i10.2641

Figure 2.

Figure 2

Effects of drugs on indomethacin-induced small intestinal lesions. Animals were given indomethacin (10 mg/kg, po) and killed 24 h later. AL-Na (250 and 500 mg/kg) or Reb (100 mg/kg) was given orally twice at 30 min before and 6 h after administration of indomethacin. (A) The lesion areas and (B) myeloperoxidase (MPO) activity were measured. C: Hematoxylin and eosin-stained microscopic observations of the rat small intestinal mucosa of the control (Cont) group; D: Indomethacin (IND); E: AL-Na (250 mg/kg); F: AL-Na (500 mg/kg); G: Reb (100 mg/kg). Each column and vertical bar represents the mean ± SE (n = 8). Significantly different from the cont group at bP < 0.01 (Student’s t-test). Significantly different from the IND group at aP < 0.05 and dP < 0.01, respectively (Dunnett’s test). AL-Na: Sodium alginate; Reb: Rebamipide.