Table 1.
Characteristics of the included studies and patients on cytomegalovirus in ulcerative colitis
| Ref. | Year of publication | Type | Design |
n |
Included patients | Severity criteria | Method of diagnosis | Anti-viral tx | Follow-up (mo) |
Short-term colectomy rate |
Long-term colectomy rate |
|||
| TX | C | TX | C | TX | C | |||||||||
| Omiya et al[8] | 2010 | Full | P1 | 10 | 10 | Moderate to severe UC | Seo’s score | Tissue PCR (IHC/HE -) | GCV | 12 | 0/10 | 0/10 | 3/10 | 0/10 |
| Zeki et al[9]1 | 2010 | Abstract | R2 | 7 | 10 | UC (no severity data) | NA | HE/IHC+ | GCV-5, | 12 | 4/7 | 7/10 | 4/7 | 7/10 |
| VGCV-2 | ||||||||||||||
| Maconi et al[10]3 | 2011 | Abstract | R2 | 6 | 14 | Moderate to severe UC | Mayo/Baron score | HE/IHC+ | GCV | 12 | 0/6 | 0/14 | 0/6 | 2/13 |
| Criscuoli et al[17] | 2011 | Full | P1 | 7 | 21 | Moderate to severe UC | Truelove/Witts | IHC +, pp65+ | GCV-5 FC-2 | 12 | 2/7 | 4/21 | 2/7 | 4/18 |
| Kim et al[12] | 2012 | Full | P1 | 14 | 17 | Moderate to severe UC | Mayo/Baron score | HE/IHC/PCR+ | GCV | hospitalization | 3/14 | 0/17 | NA | NA |
| Roblin et al[13]3 | 2011 | Full | P1 | 8 | 8 | Moderate to severe UC, failure of CS +rescue therapy (IFX/CSA) | Mayo | qPCR, IHC/HE- | GCV | ≥ 10 | 1/8 | 2/8 | 3/8 | 2/8 |
| Al-Zafiri et al[14]3 | 2012 | Full | R2 | 7 | 8 | Hospitalized UC | NA | IHC/HE+ | GCV | hospitalization | 3/7 | 0/8 | NA | NA |
| Maruyama et al[15] | 2012 | Abstract | R2 | 4 | 12 | Moderate to severe UC | NA | IHC/HE+ | GCV | Hospitalization | 3/4 | 0/12 | NA | NA |
| Kopylov et al[16] | 2013 | Full | R2 | 7 | 6 | UC | NA | IHC/HE+ | GCV-6 VGCV-1 | 13 | 1/7 | 0/6 | 3/7 | 0/6 |
1
P: prospective design;
2
R: retrospective design;
3
Some of the data was obtained through personal communication; TX: Patients treated with antivirals; C: Patients who did not receive antivirals. PCR: Polymerase chain reaction; qPCR: Quantitative PCR; IHC: Immunohistochemistry; HE: Hematoxylin-eosin staining; pp65: Antigenemia; GCV: Gancyclovir; VGCV: Valgancyclovir; FC: Foscarnet. Short -term outcome- during the initial hospitalization or within 30 d of the diagnosis; long-term outcome- > 3 mo after the initial hospitalization.