Table 3. Connection of glycosylation features related to fucosylation, sialylation and bisecting GlcNAc with measures of severity of inflammatory response (highest CRP, number of leukocytes, number of trombocytes).
Glycan feature | Phenotype | R | R2 | p | p adjusted |
---|---|---|---|---|---|
FG0n total/G0n | max CRP | −0.393 | 0.155 | <0.001 | 0.003 |
Fn total | max CRP | −0.361 | 0.131 | 0.001 | 0.006 |
FG1n total/G1n | max CRP | −0.336 | 0.113 | 0.002 | 0.010 |
FBS total/FS total | thrombocytes | −0.264 | 0.070 | 0.010 | 0.042 |
FS/S | max CRP | −0.277 | 0.077 | 0.010 | 0.042 |
FG2n total/G2n | max CRP | −0.228 | 0.052 | 0.034 | 0.119 |
S | leukocytes | 0.192 | 0.037 | 0.061 | 0.181 |
S | max CRP | 0.153 | 0.023 | 0.158 | 0.415 |
FG0n total/G0n | thrombocytes | 0.085 | 0.007 | 0.412 | 0.888 |
FS/S | thrombocytes | 0.084 | 0.007 | 0.423 | 0.888 |
ΔFG0n total/G0n | max CRP | 0.390 | 0.152 | 0.000 | 0.003 |
ΔFG1n total/G1n | max CRP | 0.270 | 0.073 | 0.011 | 0.081 |
ΔFS/S | max CRP | 0.264 | 0.070 | 0.014 | 0.081 |
ΔFG2n total/G2n | max CRP | 0.211 | 0.045 | 0.050 | 0.224 |
ΔS | leukocytes | −0.165 | 0.027 | 0.109 | 0.392 |
ΔFG1n total/G1n | thrombocytes | 0.151 | 0.023 | 0.148 | 0.443 |
ΔFBStotal/FStotal | thrombocytes | 0.140 | 0.020 | 0.177 | 0.456 |
ΔFG2n total/G2n | leukocytes | −0.107 | 0.012 | 0.299 | 0.539 |
ΔFG0n total/G0n | thrombocytes | 0.112 | 0.013 | 0.283 | 0.539 |
ΔS | max CRP | −0.125 | 0.016 | 0.248 | 0.539 |
FG0n/G0n - the percentage of fucosylation of agalactosylated structures without bisecting GlcNAc;
Fn total - the percentage of all fucosylated structures in total neutral glycan fraction;
FG1n total/G1n - the percentage of fucosylation of monogalactosylated structures;
FBS total/FS total - ratio of all fucosylated sialylated structures with and without bisecting GlcNAc;
FS/S – level of fucosylation of sialylated structures;
FG2n total/G2n - the percentage of fucosylation of digalactosylated structures;
S – the percentage of sialylated structures;
FG0n total/G0 - the percentage of fucosylation of agalactosylated structures;
Δindicates the difference between day 0 and day 1.