Fig. 8.

Caffeine accelerated recovery from propofol anesthesia. Adult rats were anesthetized with 3% isoflurane for 8 min at which time an intravenous line was inserted. The animals were allowed to wake and then a bolus of propofol (4 mg/kg) was injected along with either saline (control, ■) or with 25 mg/kg caffeine in saline (○). All rats became unconscious again within 5 s of propofol injection. The animals were allowed to wake. The same animals were used as controls and to test caffeine (n = 16 per group).