Table 1.
Perforant path-dentate gyrus low-frequency stimulation data summary
| Condition | LFS Paradigm | LPP/MPP | n | Normalized fEPSP 1-H Post-LFS |
|---|---|---|---|---|
| Awake, freely moving | 900 pulses, 1 Hz | LPP | 6 | 91.3 ± 2.7 |
| Awake, freely moving | 900 pulses, 1 Hz | MPP | 6 | 102.9 ± 10.4 |
| Pentobarbital | 900 pulses, 1 Hz | LPP | 5 | 109.4 ± 2.5 |
| CPP + pentobarbital | 900 pulses, 1 Hz | LPP | 6 | 118.5 ± 6.6 |
| Pentobarbital | 900 pulses, 1 Hz | MPP | 8 | 120.2 ± 7.1 |
| CPP + pentobarbital | 900 pulses, 1 Hz | MPP | 6 | 100.4 ± 4.7 |
| Urethane | 900 pulses, 1 Hz | LPP | 5 | 123.0 ± 4.2 |
| CPP + urethane | 900 pulses, 1 Hz | LPP | 7 | 110.9 ± 8.3 |
| Urethane | 900 pulses, 1 Hz | MPP | 5 | 132.2 ± 7.1 |
| CPP + urethane | 900 pulses, 1 Hz | MPP | 5 | 104.0 ± 9.6 |
| Pentobarbital | Low-intensity 900 pulses, 1 Hz | LPP | 6 | 111.5 ± 5.5 |
| Pentobarbital | Low-intensity 900 pulses, 1 Hz | MPP | 5 | 111.8 ± 9.0 |
| Pentobarbital | 900 paired pulses | LPP | 4 | 119.0 ± 6.7 |
| Pentobarbital | 900 paired pulses | MPP | 5 | 132.2 ± 10.6 |
| Pentobarbital (permanent electrodes) | 900 pulses, 1 Hz | LPP | 6 | 94.9 ± 9.1 |
| CPP + freely moving | 900 pulses, 1 Hz | LPP | 7 | 94.4 ± 8.4 |
| Vehicle + freely moving | 900 pulses, 1 Hz | LPP | 6 | 89.0 ± 12.1 |
Normalized field excitatory postsynaptic potentials (fEPSPs) reflect means ± SE. LFS, low-frequency stimulation; LPP, lateral perforant path; MPP, medial perforant path; CCP, (+/−)-cyclopiperidine-6-piperiperenzine.