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. 2014 Mar 11;5:40. doi: 10.3389/fphar.2014.00040

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Copyright © 2014 Wang, Levinson, Sun and Heinbockel.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A–C) A GABA_A receptor antagonist rather than AMPA/kainate or NMDA receptor antagonists blocked the α-asarone-induced inhibition of MCs. (A) Original recording obtained from a MC shows that α-asarone-induced suppression of neuronal firing recorded in a representative MC in the presence of iontropic glutamate receptor antagonists CNQX and D-AP5. (B) Current trace shows that α-asarone failed to evoke the inhibitory effects in the presence of fast synaptic blockers. (C) In gabazine, a GABA_A receptor antagonist, the firing rate remained the same. Current trace shows that gabazine eliminated the inhibitory effects of α-asarone.