FIG. 8.

Representations of the spinal cord injury (SCI)-induced temporal patterns of expression of Wnt mRNAs in mice and their correlation with previously reported patterns in rat. (A) Summary of the integrated mRNA expression for all measured Wnt Ligands (Wnt1 to 19, except for Wnt8b), Fz receptors (Fz1 to 10), the Wnt canonical inhibitors (Dkk-1/4), sFRP (sFRP-1/3), and Wif1. (B) Comparative representation of the patterns of expression obtained for each category between mice and rats in response to SCI (obtained from Fernández-Martos et al., 2011²⁷). The results show inverse patterns of expression, with a rat up-regulation and mice down-regulation for Wnt ligands and receptors and, contrarily, rat down-regulation and mice up-regulation of inhibitors, with as a highlight the prominent increase of the unspecific inhibitor, Wif1, observed in mice. Fz, Frizzled; mRNA, messenger RNA; sFRP, secreted Frizzled-related protein; Wif1, Wnt inhibitory factor 1; d, days. Color image is available online at www.liebertpub.com/neu