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. Author manuscript; available in PMC: 2015 Mar 15.
Published in final edited form as: Dev Biol. 2014 Jan 15;387(2):191–202. doi: 10.1016/j.ydbio.2014.01.002

Figure 5. Microarray analyses from Klf5ERΔ and Klf5fl/fl tissues reveal up-regulation of several regeneration associated genes and down-regulation of known Klf5 targets.

Figure 5

Panels A-D represent microarray data from day 3 tamoxifen-treated Klf5ERΔ colonic tissues normalized to control Klf5fl/fl tissues. RNA extracted from mice was analyzed using an Illumina Mouse Array to specify gene expression patterns. Panel A and C display genes that were highly up-regulated in Klf5ERΔ colonic tissues when compared to controls. Presence of several regeneration associated (Reg) genes were noted. Panels B and D display genes that were significantly down-regulated in Klf5ERΔ colonic tissues when compared to controls. We observed many previously known targets of Klf5 to be down-regulated.