Table 5. Impact of including rates of pre-treatment loss to follow-up on national tuberculosis programme indicators in hypothetical programmes in Africa and Asia with 100 000 individuals and DOTS strategy targets (70% case detection, 85% cure) theoretically achieved, 2011.

Indicator	Africa			Asia
	Outcomes reported under current WHO targets	After including tuberculosis patients lost to follow-up before treatment		Outcomes reported under current WHO targets	After including tuberculosis patients lost to follow-up before treatment
No. of cases	100 000	100 000		100 000	100 000
Cases detected, no. (%)	70 000 (70)	85 366a (85)		70 000 (70)	80 460a (80)
Tuberculosis patients lost to follow-up before treatment, no. (%)	Unknown	15 366 (18)		Unknown	10 460 (13)
Cases started on treatment, no. (%)	Unknown	70 000 (82)b		Unknown	70 000 (87)b
Patients cured, no. (%)	59 500 (85)	59 500 (70)c		59 500 (85)	59 500 (74)c
Deceased tuberculosis patients, no. (%)	4200d (6)	12 498e (12)		2100d (3)	3251e (3)

WHO, World Health Organization.

^a Calculated as [1 ÷ (1 − fraction lost to follow-up before treatment)] × number of cases detected. For Africa: [1 ÷ 0.82] × 70 000; for Asia: [1 ÷ 0.87] × 70 000.

^b Percentage calculated as number of cases initiating tuberculosis treatment divided by the number of cases detected. For Africa: 70 000 ÷ 85 366; for Asia: 70 000 ÷ 80 460.

^c Percentage calculated as the number of patients who successfully completed treatment divided by the number of cases detected. For Africa: 59 500 ÷ 85 366; for Asia: 59 500 ÷ 80 460.

^d Number obtained from WHO country database.

^e Calculated as the number of deceased tuberculosis patients plus the product of the number of cases lost to follow-up before treatment and the median case fatality rate found in this review. For Africa: 4200 + (15 366 × 0.54); for Asia: 2100 + (10 460 × 0.11).

Note: Estimates for the western Pacific region not included, as only one study was identified.