Skip to main content
. 2014 Mar 10;211(3):387–393. doi: 10.1084/jem.20131685

Figure 4.

Figure 4.

The turnover rate of tau in hippocampus and ISF is low. Human tau expression in anti-aggregant mice was switched off for the indicated lengths of time by doxycycline, and human tau (black circle) and murine tau (white square) levels in hippocampus were measured by ELISA (A; n = 5–7/group/time point; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001). Human tau (black circle) and lactate (white square) in ISF after switch-off were measured by ELISA (B; n = 4–5/group/time point; **, P < 0.01). The plot of the common logarithm of percent tau in hippocampal lysates or ISF versus time was linear in both groups studied. The slope from the linear regressions from log (% tau) versus time was used to calculate the half-life (t1/2) of elimination for tau from hippocampus (C) and ISF (D). Each mouse studied in A–D was investigated independently. Any treatment effects were compared with baseline values obtained from mice studied at time zero. Error bars represent SEM.

HHS Vulnerability Disclosure