Table 2.
Antistaphylococcal and antienterococcal activities of 4- and 5-substituted 1-phenylnaphthalenes.
| Compound | aMIC (µg/mL) | |||
|---|---|---|---|---|
|
S. aureus 8325-4 (MSSA) |
S. aureus ATCC 33591 (MRSA) |
E. faecalis ATCC 19433 (VSE) |
E. faecalis ATCC 51575 (VRE) |
|
| 1 | 4.0 | 8.0 | 8.0 | 8.0 |
| 2 | 4.0 | 4.0 | 4.0 | 4.0 |
| 3 | 2.0 | 2.0 | 2.0 | 2.0 |
| 4 | 2.0 | 4.0 | 2.0 | 4.0 |
| 5 | 4.0 | 4.0 | 8.0 | 8.0 |
| 6 | 2.0 | 4.0 | 2.0 | 4.0 |
| 7 | 4.0 | 4.0 | 4.0 | 8.0 |
| 8 | 0.5 | 2.0 | 2.0 | 4.0 |
| 9 | 1.0 | 2.0 | 2.0 | 2.0 |
| 10 | 1.0 | 8.0 | 8.0 | 8.0 |
| 11 | 2.0 | 8.0 | 8.0 | 8.0 |
| 12 | 2.0 | 8.0 | 8.0 | 8.0 |
| 13 | 4.0 | 8.0 | 4.0 | 8.0 |
| 14 | 2.0 | 8.0 | 8.0 | 16 |
| 15 | 1.0 | 4.0 | 4.0 | 4.0 |
| 16 | 8.0 | 16 | 8.0 | 8 |
| 17 | 8.0 | 16 | 16 | 16 |
| 18 | 2.0 | 8.0 | 4.0 | 4.0 |
| 19 | 2.0 | 8.0 | 4.0 | 4.0 |
| Sanguinarine | 2.0 | 2.0 | 8.0 | 16 |
| Chelerythrine | 4.0 | 4.0 | 32 | 32 |
| Oxacillin | 0.06 | >64 | 8.0 | >64 |
| Vancomycin | 1.0 | 2.0 | 1.0 | >64 |
| Erythromycin | 0.13 | >64 | 1.0 | >64 |
| Tetracycline | 0.06 | 64 | 0.5 | >64 |
| Clindamycin | 0.03 | >64 | 2.0 | >64 |
MIC is defined as the lowest compound concentration at which bacterial growth is ≥90% inhibited.
a
Minimum inhibitory concentration (MIC) assays were conducted in accordance with Clinical Laboratory Standards Institute (CLSI) guidelines for broth microdilution [27].