Table 2.

Representative example of flow cytometric analysis of antibody-dependent cell-mediated cytotoxicity (ADCC) activity mediated by CD3⁻CD56⁺ natural killer (NK) or CD3⁺CD8⁺ T effector cells and anti-human endogenous retroviruses (HERV) antibodies.

HERV peptide epitope	CD56+			CD8+
	PI	I	Increment	PI	I	Increment
HERV-H/F Gag	2·05	39·4	37·35	0·77	4·75	3·98
HERV-F Gag	2·77	3·05	0·28	0·41	0·68	0·27
HERV-H H1 Env	12·30	27·7	15·40	0·63	0·97	0·34
HERV-H H2 Env	6·06	8·83	2·74	0·55	1·57	1·02
HERV-H H3 Env	2·00	2·61	0·61	0·63	0·71	0·08
HERV-F Env	6·65	6·73	0·08	0·83	0·42	–
HERV-W W1 Env	3·73	2·64	–	0·52	0·38	–
HERV-W W2 Env	4·40	2·69	–	0·49	0·86	0·37
HERV-W W3 Env	4·98	2·52	–	0·39	0·56	0·17

Effector cells sourced from effector A: NK cells (CD56⁺) and cytotoxic T cells (CD8⁺), respectively. Target cells were the B lymphoblastoid cell culture MS1874. Results shown are % CD107a⁺ CD56⁺ cells and % CD107a⁺ CD8⁺ cells with added antibodies from preimmune (PI) or immune (I) serum after immunization with each specific HERV peptide.