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Bim–/– mice develop an aggravated chronic dextran sulphate sodium (DSS)-induced colitis compared to wild-type (wt) mice. (a) Percentage body weight loss [± standard deviation (s.d.)]. (b) Statistical analysis of colonoscopy score [murine endoscopic index of colitis severity (MEICS)]. Colonoscopy was performed on the day prior to euthanizing the animals. Representative images demonstrate colonoscopy pictures derived from DSS-treated wt mice and Bim–/– mice. *P < 0·05.
